The compost metagenome as a source of T4 bacteriophage pyrimidine dimer glycosylase homologues

Compost is a promising source of thermotolerant enzymes for their application in biotechnology. Homologues bacteriophage T4 DNA glycosylase can find pharmaceuticals and perfumery. Five homologues pyrimidine dimers T4, product the denV gene, were found by comparing using DELTA-BLAST algorithm with compost metagenome proteins. Phylogenetic analysis sequences enzyme was carried out Maximum Likelihood MegaX software package. Thus, an interesting spectrum proteins, repair enzyme, found. After structural modeling, they be tested thermal stability as basis therapeutic prophylactic drugs.